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Calf Milk Replacer Guide – What to Use and Why

14 October 2025

There are many benefits of feeding a calf milk replacer (CMR) over whole milk, including:

  • Reduced risk of disease transfer (particularly Johne’s)
  • High bacterial load
  • Antibiotic residues
  • Consistency

However, there are many different CMR’s available, and it can be difficult to compare products and decide which one is best for your calves and rearing system. The aim of this guide is to discuss what makes a quality product, what to look for on a label and how to assess the potential impact of a CMR on calf performance.

Understanding CMR Specifications

The specification of a CMR is mainly based on the fat (oil) and protein content of the powder. Products can vary greatly, with the protein content ranging from 20 to 26% and the fat content ranging from 16 to 25%. Fibre and ash levels will also be declared on a label, along with added minerals, vitamins and other nutritional additives. Guidance on what to look for when interpreting a label is given below:

Protein

Protein should be a minimum of 20% but if you are looking to maximise weight gains on dairy heifers then look for 24-26% protein for faster leaner growth under good management conditions.

Oil

The higher the oil, the higher the energy content. If this is less than 16% then energy could be limiting for health and growth depending on the feed rate and particularly during cold weather. There is evidence to suggest that higher oil CMR’s (over 20%) can limit starter feed intake. However, the key to good intakes is to provide starter feed little and often to keep it fresh, access to chopped forage and having at least a two-week gradual weaning process off milk.

Ash

Ash indicates the mineral content of the CMR and should not be more than 8%.  Any higher and there is increased risk of nutritional scour. Aim for calcium to be a minimum of 0.8% and phosphorus 0.7% for good skeletal development.

Fibre

Fibre content is a good indicator of digestibility and quality. Over 0.15% indicates the presence of plant-based proteins which tend to be less digestible than milk-based proteins, and so the lower the better.

Additives

Nutritional additives include ingredients such as MOS (mannan-oligosaccharides which are complex carbohydrates from yeast cell walls), prebiotics, probiotics and plant extracts. These additives are included to aid gut health and help develop the population of healthy gut bacteria, reduce disease risk and benefit feed conversion efficiency and growth performance.

Skim versus whey (dairy protein sources)

When comparing milk proteins in CMR’s you should consider whether they are derived from whey or skim. The protein in whole milk is made up of approximately 80% skim (casein) and 20% whey (albumin and globulin) proteins. The main difference between skim and whey is how they are digested.

Whole milk and skim-based CMR’s form a clot in the abomasum due to the action of digestive enzymes on casein, resulting in much slower digestion. The clot can take up to 12 hours to be digested in the abomasum, providing a steady release of nutrients. 

Whey protein is a by-product of cheese making and whey-based CMR’s do not form a clot in the abomasum, being digested in the small intestine. Digestion is also much quicker, usually over 2 to 3 hours. Whey may be listed on the product label as dried whey, whey protein concentrate or delactosed whey. The difference between these is the amount of lactose and minerals removed from the whey. Dried whey contains around 12% protein, whereas delactosed whey and whey protein concentrate contain around 27% and 35% protein respectively. The quality and digestibility of whey can be influenced by the type of cheese it is derived from and how it is processed e.g. drying temperatures and handling procedures, which can ultimately affect calf performance.

Ranking Different Protein Sources

Dairy proteins are typically more digestible than non-milk proteins and provide a desirable amino acid profile for calf growth. They should be first on the list of ingredients in a CMR. If using a skim-based product, the skim content should be a minimum of 50% to promote good clot formation in the abomasum.

A summary of preferred, acceptable and questionable protein sources in CMR’s are given below.

Table 1. Typical protein sources found in CMR's.

 

PreferredAcceptableQuestionable/not recommended
Skim milk powderSoy protein isolateSoy flour
Whey protein concentrateSoy protein concentrateModified potato protein
Whey powderProtein modified soy flourDried distillers solubles
Buttermilk powderDelactosed whey (27%)Dried brewer’s yeast
Hydrolysed wheat glutenEgg proteinOat flour
Potato proteinWheat flour
Pea protein

It is important that you read the product labels. Ingredients will be listed in descending order of inclusion. Milk-based proteins should be higher on the ingredient list compared to plant-based proteins.

Plant-Based Proteins

Plant-based protein sources are commonly found in CMR’s. Calves will always perform better on milk-based proteins compared to plant-based proteins, which are a cheaper alternative but generally less digestible. The most common plant-based sources are hydrolysed wheat gluten, pea protein, soy protein (soy flour, soy protein isolate and soy protein concentrate) and potato protein.

Hydrolysed wheat gluten is the most used non-milk protein in the UK. It is a high quality, economical protein source, manufactured from wheat flour by separating the gluten protein from wheat starch.

Pea protein is also favourable for its high digestibility and absence of anti-nutritional factors. However, it does not tend to mix as well and sediments out rapidly. If included in a CMR, check the buckets after feeding to see if residual solids remain.

Soy protein has low digestibility and amino acid content. It can cause an allergic reaction in the gut tissue, decrease available protein to the calf and result in diarrhoea. This source of protein is best used in calves over three weeks of age. Soy proteins may contain anti-nutritional factors which can cause scours if fed in excess. If it is on the label, it should be present at very low levels (low down on the ingredient list).

Potato protein isolates have had the carbohydrate fraction (fibre) removed through special processing. This also removes the allergens, inhibitors and other anti–nutritional factors usually associated with plant proteins. They are low in fibre and lower in cost than milk proteins, making them a good choice for milk replacer.

Egg proteins are commonly used in commercial milk replacers with excellent results. Egg proteins are often referred to as the perfect protein, given their excellent amino acid content and digestibility. They are also less expensive than milk proteins, thereby helping reduce the cost of CMR.

Understanding Fats

Fat is present in cow’s milk in the form of triglycerides, surrounded by a membrane to make a milk fat globule. The most common fatty acid in milk triglycerides is palmitic acid, a saturated fatty acid. The best source of palmitic acid among vegetable fat sources is palm oil. Milk fat also contains short and medium-chain fatty acids. These are readily available energy sources and have helpful bacteriostatic and bactericidal effects in the gut.

Milk replacers often include coconut oil to provide medium chain fatty acids. As coconut and palm oil tend to be the most digestible fat sources, they are commonly used. Fat sources rich in unsaturated fatty acids, such as soya oil or sunflower oil, give lower growth rates and can increase diarrhoea, so are best avoided.

Understanding Osmolality For Optimal Digestion

Osmolality refers to the concentration of a solution expressed as the total number of solute particles per kilogram. Cow’s milk has an osmolality of around 300mOsm/kg, which is the same as a calf’s blood. As these are similar, this enables optimal digestion and the absorption of nutrients into the bloodstream.

The osmolality of a CMR will vary depending on the concentration of lactose and minerals in the product but can often be higher than that of the calf’s blood, potentially leading to problems when the CMR is mixed at a high inclusion rate.

If a CMR uses fat as its main energy source, its osmolality will be lower than one that is relying more on lactose to provide energy. Whey based powders will have varying osmolality depending on their lactose content.  Better quality whey-based milk replacers will have a lower percentage of lactose and thus a higher fat percentage, resulting in a lower osmolality.

If the osmolality of milk is too high, fluid is effectively drawn from the calf’s blood into the intestine. This can cause diarrhoea and lead to dehydration. In extreme cases, there is delayed abomasal emptying, putting calves at risk of bloat. Regular feeding of high osmolality CMR has also been shown to damage the lining of the gut. This not only has an effect on the calf’s ability to digest nutrients properly, but can increase the permeability of the gut lining, making it easier for pathogens to transfer into the bloodstream, causing disease.

To avoid high osmolality, it is recommended that CMR’s are mixed at a maximum concentration of 15% (unless advised otherwise by the manufacturer/supplier) and plentiful fresh water is available. Even if the CMR is mixed properly, the osmolality in the calf’s gut is dependent on the calf drinking enough water and the health of the calf, whether it is scouring and dehydrated.

Importance of water

Access to ad-lib clean water is important and provision of water from day 1 is a legal requirement. Remember, milk bypasses the rumen via the oesophageal groove and goes direct into the abomasum for digestion. When the calf drinks water it goes into the rumen, where it is essential to help develop a healthy rumen microbe population and enable the digestion of starter feed. As a rule of thumb, a calf needs 4 litres of water to digest 1kg of starter feed. Even though starter feed intakes are very low in the first 3 weeks of life, water is still essential for rumen health and to help maintain the osmolality of the calf’s blood.

Calf in  a calf pen with two blue buckets

Selecting a milk replacer for dairy heifers or dairy beef calves

For dairy heifer replacements, aim for a CMR with a minimum 23% crude protein. For dairy heifers where high growth performance and calving at 22-24 months is the target, then a higher CMR of 25-26% protein is recommended (and fed at a minimum 900g/day). Higher protein milk replacers may tend to be lower in oil (energy) and require a high feed rate to ensure sufficient energy is provided to help utilise the higher level of protein. This will help stimulate lean body growth (both skeletal and muscle growth), with less fat deposition compared to a lower protein CMR. Generally the more milk fed, the better the growth performance.

For dairy beef calves, typically milk replacers may tend to have lower levels of protein, between 20-22%.

Calf Performance

While skim-based powders are often thought to be superior in terms of calf performance, similar performance can be achieved in calves reared on whey versus skim-based milk CMR’s. Research from Harper Adams University showed no difference in liveweight gain and coat bloom scores in Holstein bulls reared on either a whey or skim-based milk replacer until weaning. However, calf performance will very much depend on the quality of whey proteins and how well they are processed.

Previous calf performance and calf bloom will provide a good indicator of CMR quality. Make sure that whatever product you are feeding, it is suited to your desired growth rate and feeding system, (e.g. ad lib, machine-controlled, twice-daily, or once daily feeding for calves over 28 days). For calves fed once a day, a skim-based CMR may be better suited, as the calf will feel fuller for longer, given its slower digestion.

You can assess your milk feeding regime and CMR quality through the Nottingham University milk replacer calculator. This allows you to input the spec of the CMR you are feeding and at what rate, along with calf weight, environmental conditions and starter feed information to calculate the predicted growth rate of the calf against the target. This calculator can be accessed from the Calf Health menu in the following link:

https://herdhealth.shinyapps.io/toolkit/

AHDB Dairy also have an on-line calf milk replacer calculated which can be accessed here: https://ahdb.org.uk/calf-milk-replacer-energy-calculator

Summary

Calf milk replacers vary greatly in terms of specification (fat and protein content) and quality of ingredients used. Always check to see that milk-based proteins are first on the ingredient list and ensure the fibre content is no higher than 0.15% - any higher and the product includes less digestible plant-based protein sources. Selecting a product will depend on the type of calves you are rearing and their target growth rate. However, increasing the inclusion rate or litres fed will likely have more of an impact on growth rate than switching to a higher spec CMR. If in doubt you can compare products and their predicted growth performance with on-line calculators.

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